In fluctuating Parkinson's disease (PD) patients, treatment of PD using the catechol-O-methyl transferase inhibitor entacapone with carbidopa ... the clinical effects of levodopa and reduces ...

Levodopa is the most efficacious agent for the treatment of motor features of Parkinson's disease but its chronic use is associated with the development of motor complications. Mounting evidence ...

These side effects include: COMT inhibitors are ... They are usually prescribed in combination with carbidopa and levodopa.

Rytary (carbidopa/levodopa ... isocarboxazid (Marplan) • can increase the risk of side effects from Rytary and the nonselective MAOI • can increase the risk of severely high blood pressure ...