To investigate this, Thomas and colleagues developed a potent and selective semisynthetic GPBAR1 agonist — α-ethyl-23(S)-methyl-cholic acid (referred to as INT-777) — based on the human bile ...
As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.
Based on promising data, I have high hopes of further testing Dr. Yoshimoto’s inhibitor.” UTSA’s drug has the potential to stop the activity of P450 8B1, the enzyme that creates cholic acid in the ...
Background and Aim: Nocturnal gastro-esophageal reflux causes heartburn and sleep disturbances impairing quality of life. Lifestyle modifications, like bed head elevation during sleep, are thought ...
Background/Aim: To determine the roles of gastroesophageal acid reflux (GER) and esophageal dysmotility on typical and atypical GERD symptoms. Methods: Two hundred thirty-six patients (159 females ...