Once scientists have zeroed in on a specific segment of DNA, how do they produce enough copies of that segment for their research? In most cases, the polymerase chain reaction, or PCR, is their ...

Steven Williams’ laboratory focuses on research designed to elucidate the molecular biology of the parasites that cause Neglected Tropical Diseases—diseases that afflict the poorest billion people on ...

Reactions contained 10 nM circularized probes, 130 nM rolling-circle primer, in 50 mM Tris·HCl (pH 7.5), 10 mM MgCl 2, 200 μg/ml acetylated BSA (Amersham) 400 μM dATP, dGTP, dCTP and dTTP.

Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...

We have devised synthetic routes to a series of three C7 modified 7-deaza-dATP derivatives with pendant aminopropyl, Z-aminopropenyl and aminopropynyl side chains. These modified triphosphates have ...