Very recent research has begun to elucidate a mechanism for the long-recognized mer-independent oxidative demethylation, likely involving some strains of anaerobic bacteria as well as aerobic ...

Magee, P. N., and Barnes, J. M., Brit. J. Cancer (in the press). Dutton, A. H., and Heath, D. F., J. Chem. Soc. (in the press). Miller, E. C., Plescia, A. M., Miller ...

RNA methylation and demethylation regulate gene transcription, pre-mRNA splicing, mRNA stability, protein translation, tumor initiation and progression. Small molecule compound inhibitors of RNA ...

Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes ...

This is most likely due to the sample transportation and storage in the laboratory and is based on the 19- demethylation of abundant endogenous steroids in the urine samples. Tests for the assessment ...