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不仅要关注细胞 还要关注细胞外基质:下丘脑神经元ECM重塑促胰岛素 ...
消除ARC神经纤维化也改善了葡萄糖稳态,降低了循环胰岛素和HOMA-IR。这些改善发生在体重发生显著变化之前,表明神经纤维化的消除对葡萄糖代谢有直接影响。在接受chABC治疗的遗传性严重肥胖和2型糖尿病小鼠中,神经纤维化消除的代谢益处进一步证实了ARC神经 ...
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