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Novel vaccine concept generates immune responses that could produce multiple types of HIV neutralizing antibodies
Prior vaccine immunogens have not generated bNAbs with the physical structure to reach and bind to gp41. To address this challenge, the researchers engineered immunogens on nanoparticles that ...
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Broadly effective vaccine design offers new hope in the fight against hepatitis C
A research team has now achieved promising results. Using epitope-focused immunogens, they were able to induce broadly neutralizing antibodies (bnAbs) in laboratory models for the first time.
Fred Hutch3y
IAVI and Moderna launch trial of HIV vaccine antigens delivered through mRNA technology
The immunogens being tested in IAVI G002 were developed by scientific teams at IAVI and Scripps Research and will be delivered via Moderna’s mRNA technology. “We are tremendously excited to be ...
Nature4y
Glycan-masked Engineered Outer Domains of HIV-1 GP120 and Their Use: Collaborative and Licensing Opportunity
In conclusion, because of their improved antigenic and immunogenic profiles, glycan-masked eOD-GT8 60mer mutants may serve as improved priming immunogens to elicit VRC01-class bnAbs in humans.