Get detailed information on Quinine, including pronunciation ... The recommended dose is 648 mg 8 hourly for 7 days. Nocturnal leg cramps- The recommended dose is 200-300 mg at bedtime.

In the course of nine months, 35 men presented themselves for treatment ... that time the veins in the left leg and upper abdomen had become larger and the cramps occurred three to four times ...

A study reveals vitamin K2 significantly lowers the frequency and intensity of nocturnal leg cramps in individuals over 65, enhancing symptom management.

But the FDA has issued repeated warnings against using quinine to prevent or treat leg cramps because it may cause serious side effects, including severe anemia, bleeding and kidney damage.