Beef gets its toughness from the connective tissues that sit throughout the meat. Many tenderizing methods, like those that involve pummeling beef ... to soften beef prior to the high-heat process of ...
Coffee contains natural acids and enzymes, which could help tenderize meat. Try adding used coffee grounds to your favorite dry rub recipe and applying the rub to the meat 2 hours before cooking.
For roasting, choose meat that's still on the bone - it has more flavour and is less prone to drying out during cooking. Likewise the best roasting joints are usually ones that aren't too lean.
When I think of wine, I think of a great fat substitute in recipes. I'm probably unusual ... sweet A very dry wine has very few natural sugars remaining, and is usually higher in alcohol.