腾讯网1mon
Mol Cell | OPA1协调线粒体ROS和整合应激反应调控细胞铁死亡
但是，关于线粒体如何调控铁死亡的具体仍然未知。 近日，来自美国阿尔伯特-爱因斯坦医学院的Richard N. Kitsis在Molecular Cell上发表了论文OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an ...
Nature5y
Mitochondrial Fusion and Division
Three central players are (1) mitofusins (outer mitochondrial membrane fusion), (2) OPA1/Mgm1 (inner mitochondrial membrane fusion), and (3) Drp1/Dnm1 (division of outer and inner mitochondrial ...
Nature19d
Functions and dysfunctions of mitochondrial dynamics
Mitochondrial fusion requires three large GTPases: the outer membrane proteins MFN1 and MFN2, and the inner membrane protein OPA1. Mitochondrial fission requires the dynamin GTPase DRP1 and the ...
Positive trial results for PYC’s eye disease therapies
PYC Therapeutics (ASX:PYC) has announced significant progress in its efforts to develop RNA-based precision medicines for ...
Baylor College of Medicine9d
Echeverria Lab Projects
These events are mediated by the mitochondrial inner membrane fusion protein optic atrophy 1 (OPA1). Using TNBC cell lines and an in vivo PDX model of residual TNBC, we found that sequential treatment ...
University of Bristol4y
School of Biochemistry prize for the best talk by a third year Biochemistry postgraduate student
In order to maintain the energy supply, respiring cells resist mitophagy by preserving an interconnected mitochondrial network via inhibition of Drp1 and impaired OMA1-dependent OPA1 cleavage. In ...
生物谷26d
Mol Cell：OPA1协调线粒体ROS和整合应激反应调控细胞铁死亡
在本研究中，作者探究了线粒体蛋白OPA1在调控铁死亡中的作用，研究发现OPA1能通过调节线粒体ROS和整合应激反应来调控细胞对铁死亡的敏感性。