Both rosiglitazone and pioglitazone are members of the thiazolidinedione (TZD) chemical class, and are associated with various side effects, including weight gain, fluid retention and oedema ...

and pioglitazone (Actos; Takeda/Eli Lilly), both introduced in 1999, are oedema and weight gain. Increased circulatory volume, a consequence of PPARγ activation, is a risk factor for cardiac ...