If you have nocturnal (nighttime) leg cramps, your doctor might prescribe quinine (Qualaquin)-even though the U.S. Food and Drug Administration has approved it for only one purpose: to treat ...

He was then allowed up, and the cramps recurred within forty-eight hours. Quinine sulfate given in an increasing daily dosage of 0.20, 0.32 and 0.50 gm. relieved but did not abolish them.

Quinine is one drug known to be effective in reducing the frequency of muscle cramps. However, the drug is out-of-bounds for most people. Quinine has FDA approval to treat certain types of malaria.

Nocturnal leg cramps- The recommended dose is 200-300 ... The World Health Organization prefers Artemisinin to quinine in treating severe cases of malaria among children, a WHO official said ...

A study reveals vitamin K2 significantly lowers the frequency and intensity of nocturnal leg cramps in individuals over 65, enhancing symptom management.