result in additive glucose-lowering effects. The purpose of the present study was to assess the effect of GLP-1, administered in combination with the thiazolidinedione, pioglitazone, on glucose ...

Pioglitazone is a medicine used in the treatment ... It is taken by mouth. Effects generally begin within half an hour and can last for up to a day.

Thus, plasma levels of total GLP-1 increased from 20.8 ± 3.2 pmol/l (saline) and 24.1 ± 3.9 (pioglitazone) to 182.5 ± 21.6 (GLP-1) and 194.8 ± 19.5 (combination) (P < 0.001). Fasting insulin ...