Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

We previously reported sustained calcineurin (Cn) activation in human lymphoid malignancies, and showed that Cn inhibitors have antileukemic effects in mouse models of T-ALL. It was unclear ...

You have full access to this article via your institution. Though activation of the calcineurin pathway can produce cardiac hypertrophy in transgenic mice 3, the results of our study indicate that ...

Topical calcineurin inhibitors are a class of medications used to treat eczema, particularly atopic dermatitis. They do not contain steroids, making them a preferred choice for certain situations, ...

Primary care physicians (PCPs) play a key role in treating young patients as they progress through the "atopic march" from ...

A 40-year-old man presented to the emergency department with a 5-day history of fevers, sore throat, fatigue, subjective ...

ROCKVILLE, Md. & EDMONTON, Alberta-- ( BUSINESS WIRE )--Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced that the Japanese Ministry of Health, Labour, and Welfare ...

Panelists discuss how the current treatment landscape for chronic graft-versus-host disease includes a range of immunosuppressive approaches, from traditional corticosteroids and calcineurin ...

Several studies have found that azelaic acid is effective in treating inflammation. 'Topical calcineurin inhibitors like tacrolimus ointment or pimecrolimus cream can be effective.' A calcineurin ...

Eczema refers to a group of skin conditions that usually appear before age 5 and clear up by adulthood. But it can persist or ...

'Perioral dermatitis is a rash characterised by red bumps and dry, flaky patches around the mouth,' says Granite. Dr Maryam ...

About LUPKYNIS LUPKYNIS is a second generation calcineurin inhibitor (CNI) with a dual mechanism of action, acting as an immunosuppressant through inhibition of T-cell activation and cytokine ...