GlobalData’s report assesses the drugs in the Double Homeobox Protein 4 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.
The genes containing developmental instructions for the body plan are known as homeobox-containing genes. The DNA code in homeobox genes directs the cell to make chemical sequences, which in turn ...
But it was by no means a given that the early life of a worm or a fly really offered any insights into humans. Then, in 1984, biologists working with fruit flies found a bit of DNA they called the ...
For example, by altering the expression and function of the engrailed homeobox genes Dr. Sillitoe has found that cerebellar patterning cues control the precise targeting of excitatory and inhibitory ...
In a broader context, the control of patterning by these genes has parallels to patterning at boundary domains in animal development — for example, as established by homeobox genes — and so ...
The new drug candidate for FSHD will combine an RNA molecule from miRecule targeting double homeobox 4 (DUX4) – a protein that is mutated in FSHD – with a nanobody developed by Sanofi that ...
One of the most down regulated genes was PAX6, which is a developmental homeobox gene that also has a role in the control of insulin secretion and is linked with diabetes and insomnia.
Key genes, such as WUSCHEL-related homeobox 4 (WOX4) and Arabidopsis NAC domain-containing protein 071 (ANAC071), are highlighted for their roles in cambial activation and callus formation ...
The antibody markers include androgen receptor (AR), homeobox protein Nkx-3.1 (NKX3.1), cluster of differentiation 44 (CD44), CD146, p53, and erythroblast transformation-specific-related gene (ERG).