Pharmaceutical Co., Ltd. has described proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase cereblon (CRBN) binding moiety covalently linked to a Bruton’s tyrosine kinase (BTK) ...

These dual-labeled hydrolysis probes consist of a 5' fluorescent reporter dye and a 3' Eclipse Dark Quencher (EDQ) coupled to the minor groove binder (MGB) moiety. Image Credit: LGC Biosearch ...