These include nociceptive pain, which is initiated by tissue damaging stimuli; inflammatory pain that is associated with the activation and recruitment of immune cells; neuropathic pain owing to ...
Therefore, drug targets that act in the brain, specifically on the central component of the trigeminovascular system, the TCC, would seem to be ideally placed to modulate this nociceptive pathway ...
Central sensitisation typically describes an increased responsiveness of nociceptive neurons in the central nervous system (CNS) to normal input. With central sensitisation, there are changes in the ...