The osteoprotegerin–RANKL (receptor activator of nuclear factor κB ligand) system is a key regulator of osteoclastogenesis that links estradiol, the immune system, vitamin D, parathyroid ...

OPG and RANKL Are Regulated by Systemic Hormones, Growth Factors, and Cytokines Cite this: Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption ...

Led first by the discovery of osteoprotegerin (OPG), a naturally occurring protein with potent osteoclastogenesis inhibitory activity, rapid progress was made to the isolation of RANKL ...

However, both drugs upregulated osteoprotegerin expression in patients with osteoarthritis, irrespective of whether they were receiving vitamin D supplements. Chondroitin sulfate and the ...