本文研究中,研究人员定义了驱动尿路上皮癌进化的基本机制并阐明了其背后的重要治疗性意义。 晚期尿路上皮癌是一种经常性的致死性疾病,其特点表现为遗传异质性较为显著。近日,一篇发表在国际杂志Nature上题为“The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution”的研究报告中,来自威尔康奈尔医学院等机构的科学家 ...
UroGen Pharma Ltd. (Nasdaq: URGN), a biotech company dedicated to developing and commercializing innovative solutions that treat urothelial and specia ...
This is the first comprehensive immunohistochemical analysis of the expression of several class I HDAC proteins (1, 2 and 3) in urothelial carcinoma. In our study, we found all three isoforms in a ...
Patients with the mesenchymal-like subtype had both significantly lower response rate and shorter survival, while the luminal-like subtypes (urothelial-like and genomically unstable) displayed the ...