OBJECTIVES To examine the comparative reliability and validity of three simple ways of rating upper limb tremor in patients with multiple sclerosis. METHODS Three examiners independently rated ...

1 Department of Psychology, University of Canterbury, and Christchurch Movement Disorders and Brain Research Group, Christchurch, New Zealand 2 Christchurch Health and Development Study, Christchurch ...

Background Corticospinal tract (CST) degeneration and cortical atrophy are consistent features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation dispersion and density ...

Professor Simon Shorvon, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK s.shorvon{at}ion.ucl.ac.uk If you ...

Background No studies have assessed the independent association of methionine homozygosity at codon 129 with the susceptibility to prion diseases, controlling for the effects of the codon 219 ...

Correspondence to: Professor David J Brooks, MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; david.brooks{at}csc.mrc.ac.uk Parkinsonian ...

Loss of nigrostriatal dopaminergic projection neurons is a key pathology in Parkinson’s disease, leading to abnormal function of basal ganglia motor circuits and the accompanying characteristic motor ...

a Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, and Autonomic Unit, University Department of Clinical Neurology, National ...

4 Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Eppendorf, Hamburg, Germany Correspondence to Dr Carsten Finke, ...

The immune system has long been recognised important in pain regulation through inflammatory cytokine modulation of peripheral nociceptive fibres. Recently, cytokine interactions in brain and spinal ...

Correspondence to Dr Manjit Singh Matharu, Headache and Facial Pain Group, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; m.matharu{at}uclmail.net Objectives To define the ...

Background In neurodegenerative diseases, alongside genetic factors, the possible intervention of environmental factors in the pathogenesis is increasingly being considered. In particular, recent ...