Hepatitis C virus (HCV) is the major cause of liver disease worldwide and a potential source of high morbidity and mortality in the future. The World Health Organization estimates that ...

So far, licensed treatments include extended-effect interferon, pegylated interferon (IFN), ribvirin (RBV), protease inhibitors such as boceprevir, telaprevir, simeprevir, and sofosbuvir and ...

Methods: We prospectively included 50 adult patients with chronic HCV (genotype 1). Patients were first submitted to triple therapy with first-generation protease inhibitors (boceprevir and telaprevir ...