The University of Michigan has identified proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to a CREB-binding protein (CREBBP; CBP) and/or histone ...

Karyotype analysis includes complete chromosome analysis of at least twenty metaphases with at least two cut karyotypes. The presence or absence of an acquired clonal chromosomal abnormality may aid ...

In parallel, it binds to chromatin that lacks histone H3 acetylation at ‘Lys-27’ (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at ‘Lys-27’ at new sites. For a complete ...

头颈部腺样囊性癌 (ACC) 与缓慢但持续的进展和全身转移有关，导致长期生存率低。ACC对常规化疗或放疗反应不佳。确定分子驱动因素可能为个性化治疗提供合理基础。在此，研究者分析了在爱尔兰接受治疗的一个患者队列的临床和详细分子基因组特征，并将起源 ...

The 5-year survival rate for hepatocellular carcinoma (HCC), a deadly form of liver cancer, is quite low. Although drug therapy is successful, patients with advanced liver cancer frequently develop ...

Background: Childhood apraxia of speech (CAS) is a genetically heterogeneous pediatric motor speech disorder. The advent of whole exome sequencing (WES) and whole genome sequencing techniques has led ...

Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to ...

Here, to our knowledge, we present the first known case of a patient with TAR syndrome who developed Philadelphia-chromosome positive (Ph+) AML, which accounts for only about 1% of newly diagnosed AML ...

Transgenic and pharmacological approaches reveal developmental elevations in glycolytic flux have an instructive role in promoting rod photoreceptor differentiation and maturation via activation of ...