引言人类基因组中存在多达三十亿的碱基对，因此在基因组学的核心挑战和最终愿景，是描述该三十亿碱基对中，每一个碱基对于特定基因调控及下游蛋白质功能的影响。因此，如何系统且高通量地对目标基因组序列进行诱导突变，成为一项核心技术挑战。当研究者聚焦于单一基因组 ...

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Axiomer “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way ...

Now, Meyer and colleagues have found a way to map m 6 A sites that is compatible with single-cell RNA-Seq. They constructed a chimera comprising the cytidine deaminase APOBEC1 and the YTH binding ...

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