Primary endocytic vesicles fuse with early endosomes, from where cargo is either recycled back to the plasma membrane or sorted into the endo-lysosomal pathway for degradation. Clathrin-mediated ...

This research also demonstrates the essential role BECLIN1 plays in endocytic trafficking. "This was unexpected, as BECLIN1 is best known for its involvement in another cellular process called ...

Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.

You will be redirected to our submission process. At the age of 120 the Golgi apparatus still keeps many of its secrets. Nonetheless, this dynamic organelle – located at the intersection of the ...

Unveiling the circuit organization and functional roles of endopiriform neurons projecting to the ventral CA1.

As the world is severely affected by COVID-19 pandemic, the use of chloroquine and hydroxychloroquine in prevention or for the treatment of patients is allowed in multiple countries but remained at ...

Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has ...

This month's cover highlights the article Deep imaging reveals dynamics and signaling in one-to-one pollen tube guidance by Yoko Mizuta, Daigo Sakakibara, and colleagues. The image shows two-photon ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

Brian's research focuses intersections between circadian rhythm and cancer. He utilizes cell line and mouse models of MYC-driven lung cancer to focus on how amplified MYC and metabolic stress disrupt ...

Alzheimer's disease is a neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. It is the most common form of dementia, affecting millions of people ...