A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell ...

T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat ...

A new study showed that SOCS1 regulation of GM-CSF signaling is dose-dependent. The study, which involved generating a novel ...

Interleukin-2 (IL-2) is a pluripotent cytokine that regulates the immune system’s response. The IL-2 receptor (IL-2R) is a heterotrimeric protein that binds to IL-2 and reacts to it on the ...

More targeted anti-cytokine approaches, using monoclonal antibodies against the cytokines Interleukin-1 (IL-1) or Interleukin 6 (IL-6), approved for the treatment of rheumatoid arthritis ...

Alterations in cytokine expression associated with inflammation ... influence on the differentiation of T cells into inflammatory interleukin-17-producing T helper cells. Akihiko Yoshimura and ...

The drug, SAR444245, is part of an emerging class of cancer immunotherapies based on interleukin-2 (IL-2). This cytokine is a protein that coaxes a powerful immune response against cancer cells.

Another major class of cytokines are the interleukin proteins, especially interleukin-1 and interleukin-6. Both of these have important roles in regulating the body's immunologic and inflammatory ...

IFI16 facilitates the inflammatory endothelial pathophenotypes observed among individuals with PAH, according to new research ...

TOPLINE: Sjögren disease (SjD) presents three distinct phenotypes ― B-cell active with low symptom burden, high systemic ...