3 endothelial cells, we conducted cell-based screening to identify compounds that inhibit the mitochondrial ROS production induced by elevated extracellular glucose. We have tested a focused ...

This important study identifies a new class of small molecules that activate the integrated stress response via the kinase HRI. Solid evidence indicates that two of these compounds promote ...

We have developed molecules called mitochondrial uncouplers that make the mitochondria less efficient, requiring the burning of more nutrients per unit of ATP. In effect, we increase respiration ...

The mitochondrial genome is the full genetic complement of a mitochondrion. Mitochondrial DNA is only a small portion of the total DNA of a eukaryotic cell and in most species is solely inherited ...

Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation. Science Immunology , 2024; 9 (99) DOI: 10.1126/sciimmunol.adp3475 Cite This Page : ...

An unexpected involvement of sodium transport in mitochondrial energy generation Study reveals an essential function of sodium transport in cellular energy generation Date: September 19, 2024 ...

Dr. Zhao's work focuses on the correction of autoimmune diseases and mitochondrial disorders, with a proven track record in treating patients with Type 1 Diabetes (T1D) and Alopecia Areata (AA ...

Mitochondria are dynamic organelles that must precisely control their protein composition according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to the mitochondrial ...