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Immunity:Notch信号揭开“沉睡”巨噬细胞的秘密:重新定义脂肪性肝病 ...
研究团队以单细胞转录组测序、谱系追踪以及条件性基因敲除小鼠模型为“显微镜”,深入到巨噬细胞的命运分水岭。他们发现,这些看似不起眼的免疫细胞在Notch信号的调控下,经历了一场跨越健康和病理的“变形”。当Notch-RBPJ信号被激活时,巨噬细胞如同被 ...
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