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Four weeks later, levels of IL-6, IP-10, MCP-1, VEGF and PDGF-AA were decreased in the eyes that received triamcinolone, whereas only VEGF levels were lower in eyes that received bevacizumab.

NECL-5, one of the members of the Necl family, significantly promotes cell movement and proliferation in cooperation with the PDGF receptor and integrin αvβ3, but NECL-5 is downregulated from ...

suggests that transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) act synergistically to direct synovial fibroblasts toward a more aggressive phenotype in response to ...

Results Transforming growth factor beta (TGFβ) and platelet-derived growth factor (PDGF) activate JNK and stimulate the phosphorylation of its downstream target c-Jun. Incubation with CC-930 prevented ...

To a large extent, these effects can be rescued by treatment of chlorate-treated embryos with PDGF-BB, suggesting that sulfated proteoglycans are mediating signaling by this peptide factor. A ...

Gelatin zymography for MMP-2 and MMP-9 was also performed. Results MMD patients exhibited significantly higher plasma concentrations of MMP-9, MCP-1, IL-1β, VEGF and PDGF-BB, and lower plasma ...

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...