Phenformin, the other previously available biguanide, was withdrawn from the market in 1977 because of an association with lactic acidosis. Buformin, another biguanide, is not available in the ...

According to an article from the Harvard Medical School, medicines containing guanidine, such as metformin and phenformin, were developed to treat diabetes. “But they fell out of favour due to ...

Lidia Ghisdal, MD; Steven Van Laecke, MD; Marc J. Abramowicz, MD, PHD; Raymond Vanholder, MD, PHD; Daniel Abramowicz, MD, PHD ...

In turn, the OXPHOS inhibitor phenformin has been evaluated in a phase I clinical trial for metastatic melanoma (NCT03026517). Preclinical studies suggest that phenformin may potentiate the effects of ...

1 Department of Breast Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China 2 Department of Breast Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China ...