Researchers found that DNA mutations from antiviral enzymes and chemotherapy fuel early bladder cancer, while abnormal ...

本文研究中，研究人员定义了驱动尿路上皮癌进化的基本机制并阐明了其背后的重要治疗性意义。 晚期尿路上皮癌是一种经常性的致死性疾病，其特点表现为遗传异质性较为显著。近日，一篇发表在国际杂志Nature上题为“The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution”的研究报告中，来自威尔康奈尔医学院等机构的科学家 ...

▎药明康德内容团队编辑 癌症仍然是威胁人类健康的头号健康难题，随着免疫检查点抑制剂、CAR-T细胞疗法等抗肿瘤策略的出现，更多癌症患者迎来了治愈的希望。与此同时，科学家发现这些疗法正面临一些新的挑战，比如耐药性、部分患者对疗法敏感度较低等。在今日的《 ...

A humanised monoclonal antibody, KEYTRUDA can enhance the immune system's potential to detect and combat tumour cells.

Adding immunotherapy to platinum chemotherapy can improve outcomes of urothelial carcinoma, but that may depend on the platinum agent used.

药王K药的一举一动总是牵动人心。近日，安斯泰来宣布日本MHLW已经批准其旗下的ADC药物恩诺单抗PADCEV与默沙东K药作为一线治疗根本性不可切除的尿路上皮癌成人患者的联合疗法。凭借优异的数据，让此联合治疗方案暨9月4日默沙东宣布获得欧盟委员会（EC ...

Researchers discovered that antiviral enzymes induce early mutations in bladder cancer, and standard chemotherapy causes ...

The study focused on urothelial carcinoma, the most common form of bladder cancer, and used advanced whole-genome sequencing ...

UroGen Pharma Ltd. (Nasdaq: URGN), a biotech company dedicated to developing and commercializing innovative solutions that treat urothelial and specia ...

This is the first comprehensive immunohistochemical analysis of the expression of several class I HDAC proteins (1, 2 and 3) in urothelial carcinoma. In our study, we found all three isoforms in a ...

Patients with the mesenchymal-like subtype had both significantly lower response rate and shorter survival, while the luminal-like subtypes (urothelial-like and genomically unstable) displayed the ...