Glutamate uptake via EAATs serves as a major mechanism for regulating the extracellular concentration of glutamate and preventing glutamate excitotoxicity. Glutamate uptake is mainly accomplished by ...

The retina is a dynamic tissue of the eye made up of many different types of cells. Scientists at St. Jude Children's ...

Researchers have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD). The study highlights microglia, the brain's primary immune ...

Tobacco and coffee contain bioactive compounds that may reduce Parkinson's disease risk by targeting key pathways such as MAO ...

Researchers have discovered that certain components of so-called 'good' cholesterol -- high-density lipoproteins (HDL) -- may be associated with an increased prevalence of cardiovascular disease ...

† Division of Neurology, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, sala 2040 – Porto Alegre, RS – CEP 90035-003, Brazil Tel.: +55 513 222 4690 Fax: +55 513 222 4690 ...

Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates ...

Stroke is the third most common cause of death and the chief cause of disability in the United States and Europe. After years of setbacks, treatments for acute stroke have finally emerged ...

but especially something called glutamate excitotoxicity, where a level of a particular neurotransmitter in the brain called glutamate can rise to a level 100 times its baseline. “We see high ...

PROG and its metabolites can upregulate gene activity through their direct actions on the PROG intranuclear receptor, but they can also act at the NMDA receptor to reduce excitotoxicity and at the ...

Background Focality of onset of amyotrophic lateral sclerosis (ALS) is not understood. Attempts to implicate physical exercise in the aetiology of ALS have provided inconsistent results. If physical ...