Hypothesis: Modulating serine biosynthesis and one-carbon metabolism in cardiomyocytes by forced expression of Phosphoglycerate Dehydrogenase (PHGDH) will ameliorate cardiac dysfunction in DCM and ...

Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy. Recently, 3-phosphoglycerate dehydrogenase (PHGDH) has been identified as being intricately associated with the ...

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因此，靶向CSCs已成为一种有希望的癌症治疗途径。最近，3-磷酸甘油酸脱氢酶(3-phosphoglycerate dehydrogenase, PHGDH)被发现与许多癌症干细胞的调控有着复杂的关系。然而，详细描述PHGDH的功能调节因子可以减轻癌症类型的干性的报告是有限的。本研究鉴定了新型“分子 ...

This study provides valuable insights into the regulation of metabolic flux between glycolysis and respiration in yeast, particularly focusing on the role of inorganic phosphate. The authors propose a ...

Magnesium plays an essential role in glucose utilization and insulin signaling. Recent advances have revealed a greater prevalence of hypomagnesemia in general, and low intracellular magnesium levels ...

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), India; Manipal Academy of Higher Education, India; ...