01 英国牛津大学拉德克利夫医院的研究团队在Cell杂志上发表了一篇论文，发现TEX264介导的核吞噬作用在维持基因组稳定性和细胞存活中发挥关键作用。

具体而言，研究者发现在脊椎动物中，溶酶体处理拓扑异构酶1裂解复合物（lysosomes process topoisomerase 1 cleavage complex, TOP1cc）促进DNA损伤。自噬对 TOP1cc ...

Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill ...

Therapy-related acute promyelocytic leukemia (t-APL) is rare and often linked to previous treatment with alkylating agents or topoisomerase II inhibitors. This report describes three cases of t-APL ...

Many types of bacteria produce an enzyme molecule called topoisomerase IV, which disentangles and separates newly replicated ...

Single nucleotide polymorphisms in genes responsible for drug metabolism can further complicate the picture by affecting drug pharmacokinetics; for example, as with the topoisomerase inhibitor ...

The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

Soft Condensed Matter and Biophysics, Department of Physics and Debye Institute, Utrecht University, Utrecht, The Netherlands ...

Scientists have identified a promising new target for cancer treatment by activating a DNA repair enzyme called TDP1, ...

SystImmune, Inc (SystImmune), a clinical-stage biotechnology company, announced that the U.S. Food and Drug Administration ...

BL-M11D1, a CD33-binding antibody-drug conjugate, is being evaluated for the treatment of patients with acute myeloid ...