In parallel, it binds to chromatin that lacks histone H3 acetylation at ‘Lys-27’ (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at ‘Lys-27’ at new sites. For a complete ...
The University of Michigan has identified proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to a CREB-binding protein (CREBBP; CBP) and/or histone ...
Background: Childhood apraxia of speech (CAS) is a genetically heterogeneous pediatric motor speech disorder. The advent of whole exome sequencing (WES) and whole genome sequencing techniques has led ...