Colorado voters will soon decide whether people convicted of certain violent crimes should be held in prison longer before ...

Rai, Mediaset, La7 (and more): who won yesterday according to the TV ratings? The television schedule for Sunday, October 6th ...

After so many years I felt the need to express a new side of myself, and I did it with a solo song». So said Damiano David on ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. InfoHiC is developed for cancer 3D genome ...

Additionally, the engineered locus may incorporate the ADAM6 gene, Pax-5-Activated Intergenic Repeat (PAIR) elements, and CTCF binding sites from a heavy chain intergenic control region. This ...

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CHARTwatch, a machine learning model, shows promise in reducing patient mortality and improving outcomes in hospital settings, according to new CMAJ study. Study: Clinical evaluation of a machine ...

在分子机制层面上，该研究团队发现CTCF-R567W突变减弱了CTCF在染色质上部分位点的结合（尤其是在具有上游结合基序特征的位点）。这种结合减弱进一步导致了局部染色质结构重组（特别是在对神经元身份识别和神经回路组装至关重要的成簇原钙黏蛋白（cPcdh）基因座）。该基因座由Pcdhα、Pcdhβ和Pcdhγ三个基因簇构成。CTCF-R567W突变主要导致Pcdhβ基因簇多个基因启动子上的CTCF结 ...

Vitamin D influences the epigenome by enhancing genomic vitamin D receptor (VDR) binding, regulating CCCTC binding factor (CTCF) levels, and affecting topologically associated domain (TAD) generation.

Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response. Here ...

Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood.