The cyberattack acccessed systems used for court-authorized wiretaps to collect internet traffic from millions of Americans.

Figure 1: Associating confidence measures with CTCF binding motifs scanned along human chromosome 21. How biologically meaningful are these scores? One way to answer this question is to assess the ...

Colorado voters will soon decide whether people convicted of certain violent crimes should be held in prison longer before ...

After so many years I felt the need to express a new side of myself, and I did it with a solo song». So said Damiano David on ...

Rai, Mediaset, La7 (and more): who won yesterday according to the TV ratings? The television schedule for Sunday, October 6th ...

在分子机制层面上，该研究团队发现CTCF-R567W突变减弱了CTCF在染色质上部分位点的结合（尤其是在具有上游结合基序特征的位点）。这种结合减弱进一步导致了局部染色质结构重组（特别是在对神经元身份识别和神经回路组装至关重要的成簇原钙黏蛋白（cPcdh）基因座）。该基因座由Pcdhα、Pcdhβ和Pcdhγ三个基因簇构成。CTCF-R567W突变主要导致Pcdhβ基因簇多个基因启动子上的CTCF结 ...

This shutoff process requires transcription, the participation of two noncoding RNAs (one of which coats the inactive X chromosome), and the participation of a DNA-binding protein called CTCF.

doi: 10.2337/db23-0508. Online ahead of print. [PMID: 38775784] (underlined are first author(s) from the Huangfu lab) Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear ...

This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...

对人的断裂图谱数据的分析表明，减数分裂DSB信号富集于含CTCF的增强子区域（图2C）。 以上结果表明，DEtail-seq技术可以为各个物种的减数分裂图谱 ...

Vitamin D influences the epigenome by enhancing genomic vitamin D receptor (VDR) binding, regulating CCCTC binding factor (CTCF) levels, and affecting topologically associated domain (TAD) generation.