NEW WATERFORD, Ohio (MyValleyTributes) – Mary Louise Vocature, 93, of New Waterford, died on Sunday, October 13, 2024, at Salem Regional Medical Center. She was born on July 15, 1931, in Unity ...
Here, the authors show that SEL1L-HRD1 ER-associated degradation modulates leptin signaling in POMC neurons by degrading misfolded leptin receptors in the ER.
Food intake is predominantly regulated within the brain by two types of neurons: AgRP (Agouti-related peptide) and POMC (proopiomelanocortin) neurons. Both are primarily found in the hypothalamus ...