Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy. Recently, 3-phosphoglycerate dehydrogenase (PHGDH) has been identified as being intricately associated with the ...

Then, part of the potential energy of 1,3BPG, released during its conversion to 3-phosphoglycerate, is coupled to the phosphorylation of ADP to ATP. The second reaction where ATP synthesis occurs ...

Potential differential diagnoses include defects in phosphofructokinase (PFK; GSD VII or Tarui disease), phosphorylase b kinase (GSD VIII), phosphoglycerate kinase (GSD IX), phosphoglyceromutase ...

因此，靶向CSCs已成为一种有希望的癌症治疗途径。最近，3-磷酸甘油酸脱氢酶(3-phosphoglycerate dehydrogenase, PHGDH)被发现与许多癌症干细胞的调控有着复杂的关系。然而，详细描述PHGDH的功能调节因子 ...