If you have nocturnal (nighttime) leg cramps, your doctor might prescribe quinine (Qualaquin)-even though the U.S. Food and Drug Administration has approved it for only one purpose: to treat ...

Vigorous rubbing of the leg or hopping about gradually ... failed to obtain complete relief from night cramps by the use of quinine sulfate, and the majority of those who obtained relief required ...

But the FDA has issued repeated warnings against using quinine to prevent or treat leg cramps because it may cause serious side effects, including severe anemia, bleeding and kidney damage.

Get detailed information on Quinine ... Adult: PO- Malaria As sulfate: The recommended dose is 648 mg 8 hourly for 7 days. Nocturnal leg cramps- The recommended dose is 200-300 mg at bedtime.

A study reveals vitamin K2 significantly lowers the frequency and intensity of nocturnal leg cramps in individuals over 65, enhancing symptom management.