Denosumab biosimilar is under clinical development by Samsung Bioepis and currently in Phase III for Post Menopausal Osteoporosis.

当女性怀孕和哺育婴儿时，她们的身体会发生变化，各种器官也会相应调整以确保母婴健康。在所有哺乳动物的演化过程中，这种适应能力是保守的。 维也纳医科大学领导的研究团队近日发现，在怀孕和哺乳期间，雌性动物的肠道也发生了巨大变化，肠道表面积增加了一倍，结构也发生了惊人的重组。 研究人员首次提供了遗传和机理证据，说明这种肠上皮扩张如何发生，并对婴儿健康产生直接影响。这项研究成果于2024年12月4日发表在 ...

Mechanistically, the researchers identified the RANK receptor/RANK ligand (RANK/RANKL) system as the key to the villous enlargement of the small intestine during reproduction, which is regulated by ...

French researchers have used a protein called receptor activator of NF-κB ligand (RANKL) to revive the structure and function of the thymus in old mice. The thymus sits in front of the heart and ...

This study provides compelling evidence of IUHCT’s potential for treatment of neurogenetic diseases The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

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Bone has the capability to adapt its density in response to mechanical stimuli through a process known as bone remodeling, which has been simulated in silico using various algorithms in several ...

Lactation is essential for life and provides essential nutrients to offspring with benefits for mothers and their progeny. In addition to its nutritional, immunologic, and psychosocial aspects ...

据了解，地舒单抗生物类似药HLX14主要作用是通过抑制RANKL（核因子κB受体活化因子配体）来阻止破骨细胞的形成、功能和存活，从而减少骨质破坏。