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Cell子刊:上海交大卢敏团队证实,“砒霜”挽救突变p53,通过免疫 ...
该研究表明,三氧化二砷(ATO,俗称砒霜)在小鼠自发成瘤小鼠模型中重新恢复 p53 突变体的功能,从而诱导自发肿瘤消退,显著延长了其生存期,并进一步揭示了 ATO 的肿瘤抑制作用依赖于 CD8 + T细胞和 IFN-γ。此外,ATO 还能激活携带各种 ...
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